KMID : 1034320170080020086
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Sleep Medicine Research 2017 Volume.8 No. 2 p.86 ~ p.91
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Neuropsychiatric Symptoms in Patients with Idiopathic Rapid Eye Movement Sleep Behavior Disorder
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Byun Jung-Ick
Shin Yu-Yong Chung Sung-Eun Shin Won-Chul
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Abstract
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Background and Objective: Idiopathic rapid eye movement sleep behavior disorder (IRBD) is a strong predictor of the development of synucleinopathies, including Parkinson¡¯s disease. Neuropsychiatric symptoms are common in patients with Parkinson¡¯s disease but have not been properly evaluated in IRBD. We used the Symptom Checklist-90-Revision (SCL-90-R) to evaluate the symptom profile of patients with drug-naive IRBD.
Methods : Consecutive drug-naive patients with video-polysomnography-confirmed IRBD that visited Kyung Hee University Hospital at Gangdong sleep clinic January 2009?November 2016 were reviewed. Age- and sex-matched healthy volunteers served as controls. Questionnaires evaluating sleep [Pittsburgh sleep quality index (PSQI) and insomnia severity index (ISI)] and depression [beck depression inventory-II (BDI-II)] were conducted with the SCL-90-R in IRBD patients and controls.
Results : Twenty patients with IRBD and 20 age- and sex-matched controls were analyzed. In IRBD patients, the mean age was 59.5, 55% were male, and the mean disease duration was 55.1 months. PSQI scores (5.7 ¡¾ 2.2 vs. 3.2 ¡¾ 1.4, p < 0.0001) and ISI scores (11.2 ¡¾ 8.7 vs. 4.1 ¡¾ 3.4, p < 0.0001) were higher in patients with IRBD than in the controls. Three IRBD patients (15%) had abnormal SCL-90-R T-scores over 70. The T-scores for phobic anxiety (p=0.009), interpersonal sensitivity (p = 0.011), psychoticism (p = 0.013), hostility (p = 0.014), anxiety (p = 0.020), and depression (p = 0.049) were higher in the patients. After adjusting for age, BDI-II scores were positively correlated with RBD disease duration (r = 0.484, p = 0.042) in IRBD patients.
Conclusions : The results of our study demonstrate that neuropsychiatric distress is more severe in patients with IRBD with no comorbidities than in otherwise healthy individuals.
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KEYWORD
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REM sleep behavior disorder, Neuropsychiatric symptom, SCL-90-R
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